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Titre 1

The APE2 nuclease is essential for DNA double strand break repair by microhomology-mediated end-joining.

Fleury H, MacEachern MK, Stiefel CM, Anand R, Sempeck C, Nebenfuehr B, Maurer-Alcalá K, Kerri Ball 1, Proctor III B, Belan O, Taylor E, Ortega R, Dodd B, Weatherly L, Dansoko D, Leung JW, Boulton SJ, Arnoult N

Online April 2023. Molecular Cell.

PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells.

Viceconte N*, Loriot A*, Abreu PL, Scheibe M, Fradera Sola A, Butter F, De Smet C, Azzalin CM, Arnoult N**, Decottignies A**. 

2020 Oct 30:rna.076281.120. (*Equal contribution, **co-corresponding authors) RNA. 

Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN.

Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J.

2017 Sept; 549(24023):548-552. Nature.

Complex interactions between the DNA damage response and mammalian telomeres.

Arnoult N, Karlseder J.

2015 Nov; 22(11):859-866. Nat Struct Mol Biol.

ALT telomeres borrow from meiosis to get moving.

Arnoult N, Karlseder J.

2014 Sep 25;159(1):11-2. Cell


Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1a at chromatin.

Boros J*, Arnoult N*, Stroobant V, Collet JF, Decottignies A.

2014 Oct 1; 34(19):3662-74. (*Equal contribution) Mol Cell Biol.


Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin.

Episkopou H, Draskovic I, Van Beneden A, Tilman G, Mattiussi M, Gobin M, Arnoult N, Londoño-Vallejo A, Decottignies A.

2014 Apr; 42(7):4391-405. Nucleic Acids Res.

Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.

O'Sullivan RJ, Arnoult N, Lackner DH, Oganesian L, Haggblom C, Corpet A, Almouzni G, Karlseder J.

2014 Feb; 21(2):167-74. Nat Struct Mol Biol.

Telomeric RNA expression: length matters.

Van Beneden A, Arnoult N, Decottignies A.

2013, 3:178. Front Oncol.

Quantitative interaction screen of telomeric-containing RNA reveals novel TERRA regulators.

Scheibe M*, Arnoult N*, Kappei D, Buchholz F, Decottignies A, Butter F, Mann M.

2013, 23(12):2149-57. (*Equal contribution) Genome Res.

The heterochromatic caps in great apes impact telomere metabolism.

Novo C, Arnoult N, Bordes WY, Castro-Vega L, Gibaud A, Dutrillaux B, Bacchetti S, Londoño-Vallejo A.

2013, 41(9):4792-801. Nucleic Acid Res.

Telomere length regulates human TERRA expression through increased trimethylation of telomeric H3K9 and HP1a.

Arnoult N*, Van Beneden A*, Decottignies A.

2012, 19:948–956. (*Equal contribution). Nat Struct Mol Biol.

Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activation.

Tilman G, Arnoult N, Lenglez S, Van Beneden A, Loriot A, De Smet C and Decottignies A.

2012 Aug 1;7(8):903-13. Epigenetics.

Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization.

Arnoult N, Schlutz-Bolard C, Letessier A, Draskovic I, Bouarich R, Campisi J, Kim S, Boussouar A, Magdinier F, Gilson E, Londoño-Vallejo JA.

2010, 6(4):e1000920. PLoS Genet.

Human POT1 is required for efficient telomere C-strand replication in the absence of WRN.

Arnoult N, Saintomé C, Ouriac-Garnier I, Riou JF, Londoño-Vallejo JA.

2009, 23(24):2915-24. Genes Dev.

Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination.

Draskovic I, Arnoult N, Steiner V, Bacchetti S, Lomonte P, Londoño-Vallejo JA.

2009, 106(37):15726-31. Proc Natl Acad Sci. U S A.

Subtelomeric DNA methylation is not required for telomeric sister chromatid exchanges in ALT cells.

Tilman G, Loriot A, Van Beneden A, Arnoult N, Londoño-Vallejo JA, De Smet C, Decottignies A.

2009, 28(14):1682-93. Oncogene.

Studying telomere replication by Q-CO-FISH: the effect of telomestatin, a potent G-quadruplex ligand.

Arnoult N, Shin-Ya K, Londoño-Vallejo JA.

2008, 122(3-4):229-36. Cytogenet Genome Res.

Replication fork movement sets chromatin loop size and origin choice in mammalian cells.

Courbet S, Gay S, Arnoult N, Wronka G, Anglana M, Brison O, Debatisse M.

2008, 455(7212):557-60. Nature.


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