Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication

G Wu, E Taylor, DT Youmans, N Arnoult, TR Cech

Nucleic Acids Research. 2025 Feb 27;53(5):gkaf177. PMID: 40087886

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EHMT1/2 inhibition promotes regression of therapy-resistant ovarian cancer tumors in a CD8 T cell-dependent manner.

Nguyen LL, Watson ZL, Ortega R, Woodruff ER, Jordan KR, Iwanaga R, Yamamoto TM, Bailey CA, To F, Lin S, Villagomez FR, Jeong AD, Guntupalli SR, Behbakht K, Gibaja V, Arnoult N, Chuong EB, Bitler BG.

Mol Cancer Res. 2024 Aug 13. doi: 10.1158/1541-7786. PMID: 39136655

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Combining EHMT and PARP Inhibition: A Strategy to Diminish Therapy-Resistant Ovarian Cancer Tumor Growth while Stimulating Immune Activation.

Nguyen LL, Watson ZL, Ortega R, Woodruff ER, Jordan KR, Iwanaga R, Yamamoto TM, Bailey CA, To F, Jeong AD, Guntupalli SR, Behbakht K, Gibaja V, Arnoult N, Cocozaki A, Chuong EB, Bitler BG.

Mol Cancer Ther. 2024 Jun 12. PMID: 38863225

 

Telomerase misbehaves after a breakup.

Arnoult N, Cech TR. 

Science. 2024 Feb 16;383(6684):702-703. doi: 10.1126/science.adn7791. PMID: 38359118

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The APE2 nuclease is essential for DNA double strand break repair by microhomology-mediated end-joining.

Fleury H, MacEachern MK, Stiefel CM, Anand R, Sempeck C, Nebenfuehr B, Maurer-Alcalá K, Kerri Ball, Proctor III B, Belan O, Taylor E, Ortega R, Dodd B, Weatherly L, Dansoko D, Leung JW, Boulton SJ, Arnoult N. 

Molecular Cell. 2023 May 4;83(9):1429-1445.e8. doi: 10.1016/j.molcel.2023.03.017. PMID: 37044098

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PAR-TERRA is the main contributor to telomeric repeat-containing RNA transcripts in normal and cancer mouse cells.

Viceconte N*, Loriot A*, Abreu PL, Scheibe M, Fradera Sola A, Butter F, De Smet C, Azzalin CM, Arnoult N**, Decottignies A**.  **co-corresponding authors

RNA. 2021 Jan;27(1):106-121. doi: 10.1261/rna.076281.120. PMID: 33127860 

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Regulation of DNA Repair pathway choice in S/G2 by the NHEJ inhibitor CYREN.

Arnoult N, Correia A, Ma J, Merlo A, Garcia-Gomez S, Maric M, Tognetti M, Benner CW, Boulton SJ, Saghatelian A, Karlseder J.

Nature. 2017 Sep 20;549(7673):548-552. doi: 10.1038/nature24023. PMID: 28959974

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Complex interactions between the DNA damage response and mammalian telomeres.

Arnoult N, Karlseder J.

Nat Struct Mol Biol. 2015 Nov;22(11):859-66. doi: 10.1038/nsmb.3092. PMID: 26581520

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ALT telomeres borrow from meiosis to get moving.

Arnoult N, Karlseder J.

Cell. 2014 Sep 25;159(1):11-12. doi: 10.1016/j.cell.2014.09.013. PMID: 25259914

 

Polycomb repressive complex 2 and H3K27me3 cooperate with H3K9 methylation to maintain heterochromatin protein 1a at chromatin.

Boros J*, Arnoult N*, Stroobant V, Collet JF, Decottignies A. (*Equal contribution)

Mol Cell Biol. 2014 Oct 1;34(19):3662-74. doi: 10.1128/MCB.00205-14. PMID: 25047840

 

Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin.

Episkopou H, Draskovic I, Van Beneden A, Tilman G, Mattiussi M, Gobin M, Arnoult N, Londoño-Vallejo A, Decottignies A.

Nucleic Acids Res. 2014 Apr;42(7):4391-405. doi: 10.1093/nar/gku114. PMID: 24500201

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Rapid induction of alternative lengthening of telomeres by depletion of the histone chaperone ASF1.

O'Sullivan RJ, Arnoult N, Lackner DH, Oganesian L, Haggblom C, Corpet A, Almouzni G, Karlseder J.

Nat Struct Mol Biol. 2014 Feb;21(2):167-74. doi: 10.1038/nsmb.2754. PMID: 24413054

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Telomeric RNA expression: length matters.

Van Beneden A, Arnoult N, Decottignies A.

Front Oncol. 2013 Jul 8;3:178. doi: 10.3389/fonc.2013.00178. eCollection 2013. PMID: 23847766

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Quantitative interaction screen of telomeric-containing RNA reveals novel TERRA regulators.

Scheibe M*, Arnoult N*, Kappei D, Buchholz F, Decottignies A, Butter F, Mann M. (*Equal contribution)

Genome Res. 2013 Dec;23(12):2149-57. doi: 10.1101/gr.151878.112. PMID: 23921659

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The heterochromatic caps in great apes impact telomere metabolism.

Novo C, Arnoult N, Bordes WY, Castro-Vega L, Gibaud A, Dutrillaux B, Bacchetti S, Londoño-Vallejo A.

Nucleic Acids Res. 2013 May;41(9):4792-801. doi: 10.1093/nar/gkt169. PMID: 23519615

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Telomere length regulates human TERRA expression through increased trimethylation of telomeric H3K9 and HP1a.

Arnoult N*, Van Beneden A*, Decottignies A.

Nat Struct Mol Biol. 2012 Sep;19(9):948-56. doi: 10.1038/nsmb.2364. PMID: 22922742

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Cancer-linked satellite 2 DNA hypomethylation does not regulate Sat2 non-coding RNA expression and is initiated by heat shock pathway activation.

Tilman G, Arnoult N, Lenglez S, Van Beneden A, Loriot A, De Smet C and Decottignies A.

Epigenetics. 2012 Aug;7(8):903-13. doi: 10.4161/epi.21107. PMID: 22722874

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Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization.

Arnoult N, Schlutz-Bolard C, Letessier A, Draskovic I, Bouarich R, Campisi J, Kim S, Boussouar A, Magdinier F, Gilson E, Londoño-Vallejo JA.

PLoS Genet. 2010 Apr 22;6(4):e1000920. doi: 10.1371/journal.pgen.1000920. PMID: 20421929

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Human POT1 is required for efficient telomere C-strand replication in the absence of WRN.

Arnoult N, Saintomé C, Ouriac-Garnier I, Riou JF, Londoño-Vallejo JA.

Genes Dev. 2009 Dec 15;23(24):2915-24. doi: 10.1101/gad.544009. PMID: 20008939

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Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination.

Draskovic I, Arnoult N, Steiner V, Bacchetti S, Lomonte P, Londoño-Vallejo JA.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15726-31. doi: 10.1073/pnas.0907689106. PMID: 19717459

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Subtelomeric DNA methylation is not required for telomeric sister chromatid exchanges in ALT cells.

Tilman G, Loriot A, Van Beneden A, Arnoult N, Londoño-Vallejo JA, De Smet C, Decottignies A.

Oncogene. 2009 Apr 9;28(14):1682-93. doi: 10.1038/onc.2009.23. PMID: 19252523

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Studying telomere replication by Q-CO-FISH: the effect of telomestatin, a potent G-quadruplex ligand.

Arnoult N, Shin-Ya K, Londoño-Vallejo JA.

Cytogenet Genome Res. 2008;122(3-4):229-36. doi: 10.1159/000167808. PMID: 19188691

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Replication fork movement sets chromatin loop size and origin choice in mammalian cells.

Courbet S, Gay S, Arnoult N, Wronka G, Anglana M, Brison O, Debatisse M.

Nature. 2008 Sep 25;455(7212):557-60. doi: 10.1038/nature07233. PMID: 18716622

                                                                                             

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